Multiple sclerosis is a chronic, immune-mediated inflammatory disease of the central nervous system.
Multiple sclerosis (MS) is a demyelinating neuroinflammatory condition, which affects the central nervous system (CNS). The CNS comprises the brain, brainstem and spinal cord. The condition is most commonly seen in young adults.
Demyelination, which is the hallmark of MS, refers to damage to the protective myelin sheath that surrounds neurons. This can lead to scarring and secondary neuronal cell loss, which results in irreversible neurological damage.
Due to the wide area of the CNS that can be affected, MS can present with a range of clinical manifestations and the disease course between individuals is unpredictable. MS is most commonly characterised by a relapsing-remitting course, which may lead to progressive neurological disability overtime.
MS is 2-3 times more common in women than men.
MS is predominantly a disease of young adults with a mean age of onset around 30 years old. It is estimated that 70% of patients with MS will present between 20-40 years old.
In the UK prevalence varies widely depending on location from a low of 179 per 100,000 in Wales to a high of 290 per 100,000 in Scotland.
The aetiology of MS remains poorly understood.
Like most inflammatory conditions of unknown aetiology, the cause is thought to be due to an abnormal immune reaction to an unknown environmental trigger in a genetically predisposed individual.
There is evidence of genetic susceptibility in MS with more than 200 polymorphisms (i.e. genetic variations).
In twin studies, the concordance rate is around 20-35% in monozygotic twins. Concordance means if one twin develops MS, what is the likelihood that the other twin, who has the same genetic material, also develops the condition. At 20-35%, it suggests genetics only play a modest role in the development of MS. The concordance rate in dizygotic twins of only 5%.
When the aetiology of a condition is unknown, we look at different risk factors that may be associated with triggering an autoimmune response that subsequently leads to the disease.
Several risk factors have been linked to the development of MS including genetics (as discussed), viral infections, geographic latitude, sunlight exposure and vitamin D levels among others.
MS is an inflammatory, demyelinating disease of the CNS, which is characterised by the presence of plaques.
The CNS is comprised of neurons, which contain a cell body and axons. Axons extend out and make connections with other neurons at synaptic junctions. These neurons are supported by glial cells, which are the most abundant cell type in the CNS.
One group of glial cells, known as oligodendrocytes, are important in formation of the myelin sheath that surrounds and insulates neuronal axons. In MS, oligodendrocytes are destroyed, which leads to demyelination and can cause axonal loss. Although there is no direct proof for an autoimmune cause, there is mounting evidence for involvement of the immune system in this pathological process.
The exact mechanism of MS is still to be elucidated. However, there appears to be activation of myelin-reactive T lymphocytes and disruption of the blood brain barrier (BBB), which allows entry of autoreactive immune cells.
Within the CNS, there is then a pro-inflammatory response with recruitment of further inflammatory cells including B lymphocytes, macrophages and microglia. Microglia can be considered as ‘macrophages of the CNS’ and thus critical in cytokine release, phagocytosis and antigen-presentation.
There is a marked immune response including an antibody-mediated response with evidence of immunoglobulins, termed oligoclonal bands, in the cerebrospinal fluid (CSF). The continued immune reaction leads to damage to oligodendrocytes with subsequent demyelination and formation of ‘MS plaques’, which contain myelin reactive T cells, B cells and macrophages.
Within the focal areas of demyelination, or plaques, there is variable degrees of inflammation, scarring (i.e. gliosis) and axonal injury. The clinical manifestations of MS depend on the location of these plaques within the CNS.
Up to 90% of cases of MS are characterised by a relapsing-remitting disease course.
MS can be categorised into different types depending on the disease course:
CIS describes the first clinical episode of suspected MS. There is no previous evidence of demyelination clinically or on neuroimaging. Oligoclonal bands in cerebrospinal fluid may be used as supportive criteria to help come to the diagnosis (see supporting investigations).
Clinical features associated with MS are determined by plaque locations within the CNS.
There are a number of clinical features that are characteristic of MS including optic neuritis, Lhermitte phenomenon (uncomfortable electric shock-like feeling triggered by neck flexion) and internuclear ophthalmoplegia (INO). Others may be common to numerous neurological pathologies including motor weakness, diplopia, gait disturbance and bladder/bowel dysfunction.
We can broadly divide the clinical manifestations into four groups: visual, motor & coordination, sensory & autonomic and cognitive & psychological.
Optic neuritis and eye movement abnormalities commonly affect patents with MS.
Optic neuritis is due to inflammation of the optic nerve and characteristically presents with partial or total unilateral visual loss that develops over days. Typical features include:
Eye movement disorders may be due to brainstem lesions that affect cranial nerves or the pathways that connect visual tracts together. Two commonly seen are INO and Abducens palsy.
Motor abnormalities can occur in any part of the body, but usually characterised by weakness and ataxia (lack of muscle coordination). The prominent motor feature in MS is progressive paraparesis and evidence of upper motor neuron signs (Spasticity, reduced power, hyper-reflexia).
Motor and coordination abnormalities may present as a typical clinical syndrome such as transverse myelitis or cerebellar syndrome.
Sensory symptoms are common in MS and seen in almost all patients during the course of the disease.
There are a whole range of sensory and autonomic symptoms that should be explored, including:
NOTE: Up to 75% report bladder dysfunction. A range of Neurogenic bladder dysfunction may occur leading to incontinence, poor bladder emptying or urinary retention.
Cognitive impairment, depression and fatigue are all extremely common in MS. It is estimated that some degree of depression may affect up to two thirds of patients with MS and this can have a negative impact on memory, attention, and concentration.
MS is primarily a clinical diagnosis, which is supported by the use of MRI.
Patients with suspected MS should be referred to a neurologist who specialises in neuroinflammatory disorders. A series of investigations can be arranged prior to referral to help exclude an alternative diagnosis (see section supporting investigations).
The diagnosis of MS is based on the clinical presentation (called an ‘attack’ or ‘relapse’), which is then confirmed by objective clinical evidence.
The McDonald criteria provides recommendations for the diagnosis of MS based on MRI findings (brain +/- spinal cord) and clinical presentation. MRI is the imaging of choice for identification of demyelinating lesions within the CNS.
The McDonald criteria was revised in 2017 and it is based on the principle that demyelinating lesions are disseminated in time and space. In other words, two independent clinical attacks would be evidence of dissemination in time and two separate lesions on MRI would be evidence of dissemination in space.
The criteria can get quite niche, but these general principles apply:
NOTE: MRI may be used to show dissemination in time by the simultaneous presence of gadolinium-enhancing and nonenhancing lesions at any time, or by a new gadolinium-enhancing lesion(s) on follow-up MRI
The differential diagnosis of MS depends on the site demyelination and presentation of neurological symptoms.
There are numerous conditions that present in a similar manner to MS. These may be other demyelinating conditions, infections, malignancy, metabolic disorder or even systemic inflammatory conditions.
Neuromyelitis optica spectrum disorders (NMOSD) is the new nomenclature for neuromyelitis optica, a condition with a very similar phenotype to MS. It refers to a series of neuroinflammatory demyelinating conditions, which preferentially affect the optic nerve and spinal cord.
The hallmark of NMOSD is an acute attack of bilateral optic neuritis or transverse myelitis. These are two common clinical manifestations of MS, but in NMOSD the presentation is more severe. It is associated with formation of an IgG autoantibody to aquaporin-4 (AQP4). Treatment is similar to MS with corticosteroids, but plasma exchange may be required for refractory cases.
Additional investigations can be used to help support the diagnosis and exclude an alternative pathology.
Cerebrospinal fluid (CSF) can be analysed following a lumbar puncture to assess for CSF-specific oligoclonal bands.
Oligoclonal bands refer to bands of immunoglobulins. The test is considered positive if oligoclonal bands identified in the CSF are not present in the serum. Therefore, a paired serum sample should be taken at the time of the lumbar puncture. They are identified in up to 95% of patients with definite MS clinically, but the test is only needed as supporting evidence in equivocal cases.
Typically, they can be used in patients with CIS as a surrogate markers of dissemination in time or as a risk estimation for those not yet meeting criteria for dissemination in space.
VER involves measuring electrical activity via a transducer over the occipital cortex in response to a light stimulus. It has limited sensitivity and specificity as a diagnostic test for previous optic neuritis and is not useful during acute episodes.
VER may be used to assess evidence of previous, asymptomatic episodes of optic neuritis. Up to 90% of individuals will have a persistent abnormality on VER following an acute episode at one year.
Useful in the work-up of MS if an alternative demyelinating condition is suspected (e.g. Neuromyelitis optica). Both AQP4 and myelin oligodendrocyte glycoprotein (MOG) antibodies are associated with NMOSD.
MS management is broadly divided into general care, managing acute relapses and disease modifying therapies.
As discussed, a range of clinical manifestations may develop in MS. Therefore, management is guided at treating a range of complications including depression, fatigue, bladder/bowel dysfunction, spasticity and poor motor function.
All patients with MS should be under the care of a specialist in MS with access to a multidisciplinary MS team including a clinical nurse specialist.
There are many aspects to the general care of patients with MS. It should be emphasised that physiotherapy and occupational therapy are critical throughout the course of the disease, especially as the disease becomes more disabling and patients require assistance with their daily activities of living
Many other aspects of care are essential in MS. These include respiratory function, swallowing and speech, vertigo, visual disturbances, seizures and sexual dysfunction. This highlights the wide-ranging effects of MS and need for a truly multidisciplinary team input.
The principle management of an acute relapse or ‘attack’ in RRMS is the use of corticosteroids.
Before treating a relapse, it is essential to rule out infection, which can lead to a deterioration in symptoms. Furthermore, a true relapse must be distinguished from fluctuations in disease course or progressive disease. Patients may require hospital admission and should always be discussed with their specialist MS team.
If a clinically significant relapse is confirmed:
NOTE: mild relapses may not require steroid therapy.
Following treatment, recovery may be expected within 2-3 months in most cases, but there can be improvement up to 12 months. If the relapse is severe, more likely to be a residual functional disability.
DMTs refer to immunomodulatory medications that aim to decrease the number of relapses and slow disease progression. The initiation of DMTs and ongoing care of patients on DMTs should be guided by MS specialists.
The initiation of DMTs have specific indications, but in general, the following principles should apply:
DMTs utilised in MS:
There are various indications for the use of DMTs within MS. DMTs can be broadly divided into first-line, second-line and third-line treatment options. Most commonly, patients with RRMS and two clinically significant relapses over the last two years may be initiated on first-line DMTs (e.g. Interferon beta, Teriflunomide or Alemtuzumab).
If the disease remains active on first-line therapy, they can be switched to second-line therapy and then third-line therapy as necessary.
NOTE: further recommendations on the use of DMTs in MS is beyond the scope of these notes.
Prognosis in MS is highly variable between patients and ability to accurately predict outcomes is limited.
In general, 25% of patients with RRMS develop SPMS within six years of diagnosis and 50% within 15 years. Following diagnosis the likelihood of walking unaided after 15 years was 60%. In patients with PPMS the median time between disease onset and requiring a waking aid was eight years in one study.
Factors linked to prognosis include:
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