Acute otitis media

Notes

Overview

Acute otitis media (AOM) refers to inflammation of the middle ear with effusion and clinical features of a middle ear infection.

Normally AOM is a self-limiting condition, commonly affecting children, though adults may also suffer. In general symptoms settle after 3 days, but can remain for a week. Bacteria or viruses are normally implicated - differentiating the two is challenging.

The majority of cases do not require antibiotic therapy and will settle with time. Though rare, serious complications such as mastoiditis, meningitis, intracranial abscess, sinus thrombosis or facial nerve paralysis may occur.

NICE define the persistent and recurrent AOM as follows:

  • Persistent AOM: Patients with a single episode of AOM who re-present with persistent or worsening symptoms.
  • Recurrent AOM: Three or more distinct episodes of AOM in the past six months, or four or more in the past twelve months, one of which was in the last six months.

Ear anatomy

Epidemiology

AOM occurs primarily in children but may also affect adults.

Children aged 0 to 4 years are most affected, with a peak in the incidence at around 9-15 months. It is more commonly seen in winter and is often associated with an upper respiratory tract infection. 

Aetiology

AOM is commonly caused by viruses, bacteria or both.

Causes of acute otitis media

Commonly identified bacteria include:

  • Streptococcus pneumoniae
  • Haemophilus influenzae
  • Moraxella catarrhalis
  • Streptococcus pyogenes

Streptococcus pneumoniae is thought to be the most common bacterial cause followed by Haemophilus influenzae.

Commonly identified viruses include:

  • Respiratory syncytial virus
  • Rhinovirus
  • Adenovirus
  • Influenza virus
  • Parainfluenza virus

Pathophysiology

Infective organisms reach the middle ear via the eustachian tube.

AOM is often associated with a preceding upper respiratory tract infection. Pathogen transmission via the eustachian tube to the middle ear may result in AOM.

It is thought that in young children the less acute angle of the eustachian tube with the wall of the pharynx results in increased transmission of pathogens, particularly when coughing or sneezing.

Clinical features

Otoscopy is key to identify signs of AOM.

Signs and symptoms depend somewhat on the age-group of the presenting patient. Remember features of an upper respiratory tract infection may be present. Otoscopy is key to identify signs of AOM.

Symptoms

Neonates

  • Irritability
  • Difficulty feeding
  • Fever

Young children

  • Holding or tugging ear
  • Irritability
  • Fever

Older children and adults

  • Otalgia
  • Hearing loss
  • Fever

Signs

  • Fever
  • Red, yellow or cloudy tympanic membrane
  • Bulging tympanic membrane or perforated membrane
  • Air-fluid level behind the tympanic membrane

Management

AOM has a spectrum of severity from a self-limiting illness to severe systemic upset requiring hospital admission.

General advice

Explain the condition to patients, as well as the fact that it is generally self limiting. Normally the illness lasts 3 days but it may last up to a week. 

Analgesia and antipyretics are advised. Paracetamol and ibuprofen (in absence of contra-indications) at appropriate doses can be used.

Antibiotics

NICE guidelines NG91: Otitis media (acute): antimicrobial prescribing, offers guidance to GPs on which children and young people may require antibiotics.

Three main options exist; no antibiotics, delayed prescription and immediate antibiotics. In all cases give safety netting advice to return if symptoms worsen, do not improve after 3 days or the patient becomes systemically unwell.

When giving a delayed or back-up prescription advise using if symptoms don’t improve after 3 days or if they worsen (rapidly or significantly).

When used amoxicillin tends to be preferred first-line (in absence of penicillin allergies) with alternatives including clarithromycin, erythromycin. Co-amoxiclav is used second line (again in the absence of penicillin allergies) in treatment resistant cases.

In ‘Children and young people who are systemically very unwell, have symptoms and signs of a more serious illness or condition, or are symptoms and signs of a more serious illness or condition, or are at high-risk of complications at high-risk of complications.’ immediate antibiotic therapy is advised. The need for urgent hospital admission should be considered (see below).

In ‘Children and young people who may be more likely to benefit from antibiotics (those of any age with otorrhoea or those under 2 years with infection in both ears).’ consider either no antibiotics, a back-up script for antibiotics or immediate antibiotics.

In ‘Children and young people who may be less likely to benefit from antibiotics.’ consider either no antibiotics or a back-up script.

Who to admit?

As always clinical judgement should be used when making decisions on the best place of care. Clinicians must consider the severity of the presentation (and any complications that may be present), home dynamics and any co-morbidities.

NICE advise the following patients should be admitted for treatment:

  • People with a severe systemic infection.
  • People with suspected acute complications of acute otitis media (AOM), such as meningitis, mastoiditis, intracranial abscess, sinus thrombosis or facial nerve paralysis.
  • Children younger than 3 months of age with a temperature of 38°C or more. 

In addition NICE advise admitting:

  • Children younger than 3 months of age. 
  • Children 3–6 months of age with a temperature of 39°C or more.

Persistent AOM

Patients with persisting (or worsening) symptoms should be reviewed. Repeat a complete history and re-examine. Consider other potential causes of similar symptoms such as otitis media with effusion (‘glue ear’). In general management follows the outline described above.

Some patients may develop chronic suppurative otitis media (CSOM) as a complication of their AOM. Those with persistent symptoms of AOM should be referred to ENT, particularly if lasting longer than 6 weeks or there is persistent hearing loss.

See the section in the above for guidance on who to admit.

Recurrent AOM

ENT referral for specialist management should be considered for those with recurrent AOM. This is especially important if there is a craniofacial abnormality, an adult patient, or debilitating / complicated AOM.

If nasopharyngeal cancer is suspected an urgent referral to ENT is required. In particular NICE advise high suspicion if:

  • ‘Persistent symptoms and signs of otitis media with effusion in between episodes (for example, conductive hearing loss) due to obstruction of the eustachian tube orifice. 
  • Persistent cervical lymphadenopathy (usually in the upper levels of the neck).
  • Epistaxis and nasal obstruction.’

Complications

Though most AOM resolves without sequelae, some may develop complications.

Frequent complications include:

  • Persistent AOM
  • Recurrent AOM
  • Perforation of tympanic membrane 
  • Hearing loss

Rarely very serious complications like mastoiditis, meningitis, intracranial abscess, sinus thrombosis and facial nerve paralysis may occur.

Mastoiditis is perhaps the most commonly occurring serious complication. It is a potentially life-threatening infection of the mastoid air cells causing pain, swelling and erythema behind the ear and systemic upset. It tends to affect younger patients, normally under the age of 5. Blood tests, fluid cultures and CT scanning forms the core of the work-up. It requires prompt recognition, early antibiotics and management that may include myringotomy and mastoidectomy. 

Further reading

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